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REFERENCES 1. Grochow LB: Busulfan disposition: The role of therapeutic monitoring in bone marrow transplantation induction regimens. Semin Oncol 20: 18, 1993 Dix SP, Wingard JR, Mullins RE, Jerkunica I, Davidson TG, Gilmore CE, York RC, Lin LS, Devine SM, Geller RB, Heffner LT, Hillyer CD, Holland HK, Winton EF, Saral R: Association of busulfan area under the curve with veno-occlusive disease following BMT. Bone Marrow Transplant 17: 225, 1996 Slattery JT, Sanders JE, Buckner CD, Schaffer RL, Lambert KW, Langer FP, Anasetti C, Bensinger WI, Fisher LD, Appelbaum FR, Hansen JA: Graft-rejection and toxicity following bone marrow transplantation in relation to busulfan pharmacokinetics. Bone Marrow Transplant 16: 31, 1995 Slattery JT, Clift RA, Buckner CD, Radich J, Storer B, Bensinger WI, Soll E, Anasetti C, Bowden R, Bryant E, Chauncey T, Deeg HJ, Doney KC, Flowers M, Gooley T, Hansen JA, Martin PJ, McDonald GB, Nash R, Petersdorf EW, Sanders JE, Schoch G, Stewart P, Storb R, Sullivan KM, Thomas ED, Witherspoon RP, Appelbaum FR: Marrow transplantation for chronic myeloid leukemia: The influence of plasma busulfan levels on the outcome of transplantation. Blood 89: 3055, 1997 Rowland M, Tozer TN: Age and Weight: Clinical pharmacokinetics: Concepts and applications. Philadelphia, PA, Williams and Wilkins, 1995, p 233 6. Vassal G, Fischer A, Challine D, Boland I, Ledheist F, Lemerle S, Vilmer E, Rahimy C, Souillet G, Gluckman E, Michel G, Deroussent A, Gouyette A: Busulfan disposition below the age of three: Alteration in children with lysosomal storage disease. Blood 82: 1030, 1993 Hassan M, Fasth A, Gerritsen B, Haraldsson A, Syruckov'a Z, van den Berg H, Sandstrom M, Karlsson M, Kumlien S, Vossen J: Busulfan kinetics and limited sampling model in children with leukemia and inherited disorders. Bone Marrow Transplant 18: 843, 1996 Gibbs JP, Czerwinski M, Slattery JT: Busulfan-glutathione conju.
Internet as a vehicle to launch a strategic dimension to their traditional business practices. Part of the reason stands from the fact that there is no security assurance; the liabilities are also ambiguous. Despite the availability of IT infrastructure, IT security products and consulting services, there is a prevalent sense of mystique and insecurity as far as Internet business is concerned. In this paper, we propose a tripartite framework to address the issues of lack of assurance and confidence. It is hoped that the I3 framework of Intrusion Detection, Internet Law Enforcement and Insurance Coverage will catalyze the process of turning Internet into a vibrant market place. 2. Problem Formulation & Principal Considerations If a small-sized business take florist shop for instance were to put up a web server to advertise the range of goods and the order information, would the shop owner end up loosing money? On a more positive note, what is the profit margin that he can expect from the sales that are attributed to the orders coming through the Internet? On the other hand, from the consumer's point of view, is there a mechanism to assure that his credit card information is well protected? There are probably more issues that need to be considered, such as non-repudiation, claims of goods not received physically and not in good conditions and so on. However, these issues are common to ordering a piece of pizza over the telephone, or a watch by mail. As they are not specific to Internet business, we shall not discuss them in this paper. Again, much as people still prefer reading hard-copied documents than their electronic versions, changing the habit of choosing merchandised objects with physical touch is not over-night. Having said that, it is up to the imagination of every money-making merchant to think of innovative and clever ways to allow the Internet shoppers to "examine" goods, say durians, through the web. Hence, we will not address the problem of habits here. Suppose, a buy-and-sell be it a flower, durian or stock option ; via the Internet is accompanied by financial commitment in the form of credit or other types of electronic arrangement, what are the instruments needed to give confidence to both the suppliers and consumers? This is the problem that this paper is addressing. From the consumer's point of view, he is worried that C1 He loses his credit card information and other personal information C2.
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The Path From Research Results to the Actual Presentation 11.30 12: 30 How to Choose and Where to Find Your Tools for Your Research Study Sandra A. Cupples, DNSc RN Heart Transplant Coordinator Washington Hospital Center Washington, DC USA 13: 30 15: Presenting for Presenters Onno van Nieuwenhuizen, MD PhD Professor Wilhelmina Children's Hospital University Medical Center Utrecht.
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Providing more tests from a single sample using fewer resources and generating faster results. What type of training and customer support programs do you have in place? The purchase of a Nova analyzer is the beginning of a long series of commitments and responsibilities from Nova to our customers. Immediately following analyzer installation, training of operators on all shifts is provided by Nova technical support and applications staff. Correlation and transition studies are included as part of the training process. We maintain a highly skilled and experienced technical support "hotline" staff to answer calls 24 7 365, as well as one-day on-site service by a trained factory representative. How do you view your relationship with the end user of your product? Nova views the relationship with our customers as a partnership to provide timely, reliable blood gas critical care testing within their hospital. Due to the urgency of blood gas critical care testing, such a partnership requires Nova to provide dependable equipment and comprehensive, responsive support. Nova support includes immediate telephone technical assistance 24 hours per day, 365 days per year; on-site service within 8 working hours; same day shipment of supplies; flexible service agreements such as our Point of Care Transition and Vendor Transition programs; and seminars and grand rounds lectures regarding various aspects of blood gas critical care testing. Nova administers a periodic Customer Satisfaction Survey to allow customers to grade our performance and offer suggestions thereby helping us improve the partnership in ways that are meaningful to them. What, in terms of cost savings benefits, does your technology bring? Nova offers more models, test menus, and price choices than any other blood gas critical care analyzer manufacturer. We feel that this large selection is necessary to meet the very different sizes and budgetary requirements of hospitals and departments. With 19 standard models with from 3-19 tests on board, customers can get the most for their money by purchasing only those tests they need. Nova's comprehensive test menus combine with rapid test results to provide clinicians with more information faster, allowing patients to be moved through the hospital more quickly. This can result in shorter length of stay that can lead to significant cost savings for both the hospital and the patient. Implementation of an overall point-of-service program with Nova analyzers can provide tremendous cost and labor savings compared to central laboratory testing. For example, installation of Nova analyzers in the ER, OR, and ICU at Fresno Community & Universal Medical Centers Fresno, CA ; resulted in an annual cost reduction in labor and consumables of over 0, 000. A similar program at University Hospitals Health System Cleveland, OH ; reduced annual labor costs by 5, 000 and annual consumables costs by 0, 000.
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TA-13. CSF DISSEMINATED MENINGIOMA Marc C. Chamberlain1 and Michael J. Glantz2; 1University of Southern California, Norris Cancer Center, Los Angeles, California; 2University of Massachusetts, Worchester, Massachusetts; USA Intracranial meningiomas are common and comprise 20% of all primary brain tumors. Meningiomas infrequently metastasize. However, there is limited data regarding CSF metastasis. Patient and methods information for this study is as follows: Eight of 200 4% ; consecutively seen meningiomas manifested CSF dissemination. CSF cytology was positive in eight, and neuroradiography was consistent with CSF dissemination in seven. Patients 6 women, 2 men ; ranged in age from 24 to 87 years mean 52 ; . All patients had prior surgery range, 15; median 2 ; , radiotherapy involved field in 7, stereotactic in 6 ; , and chemotherapy hydroxyurea in 8 ; . Concomitant metastases were seen in all patients and were both intraneural subarachnoid or ventricular tumor; intracranial in 8; spinal cord in 4 ; and extraneural subcutaneous, cervical lymph nodes, orbit or pulmonary in 5 ; . Treatment utilized both systemic temozolomide in 4, CPT-11 in 3, hydroxyurea in 3, ainterferon in 2 ; and intraventricular liposomal ara-C in 7, thiotepa in 1, busulfan in 1 ; chemotherapy. We observed treatment-related toxicity in 8 patients, including chemical meningitis 8, grade 2 ; . Best response comprised stable disease in 7 and progressive disease in 1. Response duration ranged.
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ASTRALIS, LTD. A Development Stage Entity ; Notes to Financial Statements NOTE 2 - SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES Continued ; Property and Equipment Furniture and equipment are recorded at cost, less accumulated depreciation computed on a straight-line basis over the estimated useful lives of the respective assets. Depreciation is computed using a four-year life for computer and office equipment, three to four years for lab equipment, five-year for automobile, seven-year for furniture and fixtures and three-year for leasehold improvements. Income Taxes Income taxes are recorded in the period in which the related transactions are recognized in the financial statements, net of the valuation allowances, which have been recorded against deferred tax assets. Deferred tax assets and liabilities are recorded for the expected future tax consequences of temporary differences between the tax basis and the financial reporting of assets and liabilities. Net deferred tax assets and liabilities, relating primarily to federal and state net operating loss carryforwards and research and development credits that have been deferred for tax purposes have also been recorded. A valuation reserve has been recorded to offset a portion of the deferred tax benefit except for amount realized through the sale of a portion of the Company's New Jersey net operating loss ; because management has determined it is more likely than not that the deferred tax assets will not be realized. See Note 7. Fair Value of Financial Instruments The Company's financial instruments, including cash and cash equivalents, accounts payable and accrued expenses, are carried at cost, which approximates fair value. Stock-Based Compensation Arrangements The Company applies the intrinsic value method of accounting prescribed by Accounting Principles Board Opinion No. 25, "Accounting For Stock Issued To Employees, " and related interpretations, in accounting for its stock-based grants to employees and directors. Under the intrinsic value method of accounting, compensation expense is recorded on the date of grant only if the current market price of the underlying stock exceeds the exercise price. The Company applies the disclosure provisions specified in SFAS No. 148, "Accounting For Stock Based Compensation - Transition and Disclosure - an Amendment of SFAS 123." The Company applies SFAS No. 123, "Accounting for Stock-Based Compensation, " in accounting for stock-based grants to non-employees. The following table illustrates the effect on net loss and earnings per share if the Company had applied the fair value recognition provisions of Statement of Financial Accounting Standards No. 123, "Accounting for Stock-Based Compensation, " to stock-based compensation and campral.
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Missed LL indicates percentage of subjects below the lower limit of busulfan exposure 900 mM min; 3.7 mg h mL % Missed UL indicates the percentage of subjects above the upper limit of busulfan exposure 1, 350 mM min; 5.5 mg h mL ; . Note that for each dose level, multiple dosing scenarios were tested. The highest average % of each scenario is listed.
1. Medeiros CR, Bitencourt MA, Zanis-Neto, J, Pasquini R. Busulfan and cyclophosphamide Bu + Cy ; conditioning regimen to transfused patients pts ; younger than 20 years old treated with bone marrow transplantation. Blood 1998; 92: 135a. Ferreira E, Ribeiro A, Bacal NS et al. Transplante de clulas tronco perifricas autlogas no tratamento de doena auto-imune: Remisso completa da anemia hemoltica por aglutininas a frio e concomitante vasculite. Bol. Soc. Bras. Hematol. Hemoter., 18 supl ; : 191-0. 3. Johnson AE, Cavalcanti FS, Gordon C, et al. Cross-sectional analysis of differences between patients with systemic lupus erythematosus in England, Brazil and Sweden. Lupus 1994; 3: 501-506. Voltarelli JC, Stracieri ABPL. Aspectos imunolgicos dos transplantes de clulas tronco hematopoticas Immunological aspects of hematopoietic stem cell transplantation ; . Medicina- Ribeiro Preto, 2000; 33: 443-462. Traynor AE, Schroeder J, Rosa RM et al. Treatment of severe systemic lupus erythematosus with high-dose therapy and hematopoietic stem cell transplantation: a phase I study. Lancet 2000; 356: 701-707. Comi G, Kappos L, Clanet M, et al. Guidelines for autologous and marrow stem cell transplantation in multiple sclerosis: a and camptosar.
Noncarcinozenic Effects The potentiaI for noncarcirrogenic toxicity to occur in an exposed individual is evaluated by comparing the exposure level with a reference dose, as follows: Hazard Quotient CDI Reference Dose If the hazard quotient is less than one, it is unlikely that even sensitive populations would experience adverse health effects. If the quotient exceeds unity, however, there may be concern for potential non-carcinogenic effects U. S. EPA, 1989 ; . To assess the overall potential for non-carcinogenic effects posed by exposure to multiple chemicals, a hazard index equal to the sum of tbe hazard quotients was calculated in accordance with U.S. EPA.
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Division of Hematology, Department of Medicine, and Departments of 1Transfusiology, 2Radiology, 3Oncology, and 4Clinical Laboratory Diagnosis, Zagreb University Hospital Center and School of Medicine, Zagreb, Croatia Aim. To assess the outcome of allogeneic stem cell transplantation in patients with aggressive lymphoma. Methods. Between 1991 and 2002, 22 patients with aggressive lymphoma in advanced phase of the disease underwent allogeneic stem cell transplantation at the Division of Hematology, Zagreb University Hospital Center. Seventeen patients received stem cells from the bone marrow. Eighteen patients underwent total body irradiation and received cyclophosphamide for conditioning, whereas the rest of the patients received busulfan and cyclophosphamide n 2 ; or chemotherapeutic protocol combining carmustine, melphalan, etoposide, and cytarabine BEAM regimen ; n 2 ; . All patients received cyclosporin and short methotrexate for the prophylaxis of graft-versus-host disease GVHD ; . Results. Three months after allotransplantation, 17 patients had complete remission, 3 patients had active disease, and the outcome in 2 patients was early death. Nine patients were alive and in complete remission for 4 to 124 months, whereas 13 patients died 8 because of disease progression and 3 because of GVHD and infection ; . The probability of overall survival at 4 years was 47%. Conclusion. Allogeneic transplantation is an effective therapy for advanced aggressive lymphoma. Because of high treatment-related toxicity and mortality, prospective trials are needed to asses the best time when to apply this treatment.
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32 Table 2. Reproductive performance of recipient mice following transplantation. Busulfan Testis Green pups Days from transplant Days from transplant to to first pup n ; first green pup n ; Recipient Treatment dpc ; * Weight [mg] Total pups %, n ; 129 x C57 Pup 9.5 10.5 11.5 Control 63.0 7.8 16 ; 34.4 1.8 12 ; 26.6 6.6 2 ; 45.5 2.0 6 ; 45.6 21.7 4 ; 73.0 7.4 7 ; 75.9 6.6 10 ; 129.2 4.6 35 ; 0 750 0, 8 ; 2 537 0.4, ; 0 110 0, 1 ; 93 674 13.8, ; 0 118 0, 2 ; 3 425 0.7, ; 39 491 8, ; 0 1982 0, 19 ; 66.4 3.4 7 ; 84.0 5.1 6 ; 90.0 1 ; 86.4 4.9 7 ; 60.0 1 ; 74.8 10.9 4 ; 54.8 2.4 5 ; 57.9 1.6 19 ; 147.5 33.5 2 ; 90.3 4.8 6 ; 135 1 ; 86 1 and capsicum.
Needless to say, Turvey's conclusion on this point was important and needed close examination. I was struck by some of Turvey's observations. First, how do we know that the print was actually in blood? None of the law enforcement reports were definitive. Eggum stated the stain was suspected to be blood and VanHaute characterized it as a red substance. Second, if the print is in Sandra's blood, how do we know it occurred on the night in question subsequent to the injury to Sandra's head? A number of people needed to be interviewed and reports reviewed to assess this issue. Spadafora maintained some hand written notes from his work on February 18 th . this issue, his notes provided: "[u]nder visible light seen reddish stain with ridge detail on handle edge of shower door." Spadafora confirmed that the shower door was secured and removed for further analysis. Analysts Harry Reed fingerprint ; and Dan Campbell serology ; of the Madison Crime Lab were interviewed. When physical evidence comes in to the lab, these two sometimes inspect the items together because their respective testing may affect evidence that the other would be interested in. Such was the case with the shower door. Reed and Campbell got together on March 17th , 1998 to unwrap and inspect the door for a "possible fingerprint with blood". The only blood found on the shower door by Reed and Campbell was the stain located on the glass of the door. They found no fingerprint in blood. Reed stated, "we were looking for prints and blood". They were doing it together so as not to interfere with each other's subsequent testing. Campbell and Reed marked the locations where the blood stain was recovered as well as the fingerprint. These markings were verified by me upon physical inspection of the door. The bloodstain mark was on the glass and the fingerprint mark on the edge of the door. A second area of inquiry dealt with the chronological timing of when Pawlak's print was left on the shower door edge and when the blood stains were left in the bathroom area. It is clear that there is no way to scientifically determine the age of fingerprints or blood stains with any specificity. One cannot conclude based on the evidence in this case as to when Jody Pawlak left her fingerprint on the shower door or when Sandra left the various bloodstains in the bathroom. It is pure speculation by Turvey that the fingerprint and the bloodstains were left subsequent to Sandra's head injury. Jody Pawlak agreed to be interviewed. She stated that she was "absolutely not at Sandra Maloney's house on February 10, 1998." She further denied helping clean up an injured Sandra Maloney or carrying her upstairs. She informed me that had she found Sandy in an injured condition, "I would have called 911." Ms. Pawlak was not surprised that her fingerprint was found. She acknowledged that she had been at the house often in the past and had used the downstairs shower. It is my belief that had Ms. Pawlak found Sandra Maloney in an injured condition, she would have called 911. This conclusion is in part based upon Ms. Pawlak's behavior the previous Sunday " February 8, 1998. On that date, Ms. Pawlak went to Sandra Maloney's residence. She found Sandra in a depressed condition. She found one particular "suicide" letter written by Sandra that stated "I hate you John. I love you Matt. Shawn and Erin and I always will." Pawlak stated at that time she crumbled it up and threw it into a garbage can in Sandy's kitchen. Ms. Pawlak took Sandra Maloney to Pawlak's residence in an effort to keep an eye on her and convince Sandra to seek help at Bellin Psychiatric Center and busulfan.
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