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ED-BLSR Description continued ; ED-BLSR: PETALUMA: BLSR-43: 123: : : RINGID 43, NODEID 3, RVRTV Y, RVTM 2.0, SRVRTV Y, SRVTM 5.0; Errors are listed in Table 7-32 on page 7-20. Emend comes with a patient information leaflet and enfuvirtide Local injection site reactions ISRs ; were by far the most common adverse event reported in patients receiving ENF and were reported in almost all patients: 97-98% The majority of patients 86% ; reported an ISR on the first study visit and continued to report ISRs throughout the study. Most ISRs were associated with pain and discomfort 95% ; : 10.6% were classified as severe, requiring analgesics or narcotic Other signs and symptoms of ISRs, including erythema, induration, and nodules cysts were substantial. 10% of patients had erythema 85 mm, 18% had induration 50 mm, and 24% had ISRs lasting for 7 days. Complications of ISRs were reported infrequently. 7% of patients discontinued the study because of ISRs, or difficulty associated with mode of administration of ENF. B. L. Stoimenov, The Institute of Physical and Chemical Research RIKEN ; Japan J. M. Rossiter, Univ. of Bristol United Kingdom ; and The Institute of Physical and Chemical Research RIKEN ; Japan T. Mukai, The Institute of Physical and Chemical Research RIKEN ; Japan and enoxacin.
MELANIE L. J. STIASSNY, Axelrod Research Curator, Ichthyology, American Museum of Natural History. K., Ueda, R., and Suzuki, S. 1983 ; Cell Struct. Funct. 8, 245254 10. Bloom, G. S., Luca, F. C., and Vallee, R. B. 1984 ; J. Cell Biol. 98, 331-340 11. Herzog, W., and Weber, K. 1978 ; Eur. J. Biochem. 9 2 , 1-8 12. Kim, H., Binder, L. I., and Rosenbaum, J. L. 1979 ; J. Cell Biol. 80, 266-276 13. Vallee, R. B., and Davis, S. E. 1983 ; Proc.Natl.Acad i. U. S. 80, 1342-1346 14. Heuser, J. E., and Kirschner, M. W. 1980 ; J. Cell Bwl. 8 6 , 212234 15. Ellisman, M. H., and Porter, K. R. 1980 ; J. Cell Biol. 8 7 , 464479 16. Hirokawa, N. 1982 ; J. Cell Biol. 94, 129-142 17. Griffith, L. M., and Pollard, T. D. 1978 ; J. Cell Biol. 78, 958965 18. Griffith, L. M., and Pollard, T. D. 1982 ; J. Biol. Chem. 2 5 7 , 9143-9151 19. Pollard, T. D., Selden, S. C., and Maupin, P. 1984 ; J. Cell Biol. 99, 33s-37s 20. Asai, D. J., Thompson, W. C., Wilson, L., Dresden, C. F., Schulman, H., and Purich, D. L. 1985 ; Proc. Natl. Acad. Sci. U. S. A 82, 1434-1438 21. Bloom, G. S., and Vallee, R. B. 1983 ; J. Cell Biol. 9 6 , 1523-1531 22. Wiche, G., and Baker, M.A. 1982 ; Exp. Cell Res. 1 3 8 , 15-29 23. Nishida, E., Kuwaki, T., and Sakai, H. 1981 ; J. Biochem. Tokyo ; 90, 575-578 24. Nishida, E., Kotani, S., Kuwaki, T., and Sakai, H. 1982 ; in Biological Functions of Microtubules and Related Structures Sakai, H., Mohri, H., and Borisy, G. G . eds ; pp. 285-295, Academic Press, Tokyo 25. Kotani, S., Nishida, E., Kumagai, H., and Sakai, H. 1985 ; J. Biol. Chem. 260, 10779-10783 26. Runge, M. S., Laue, T. M., Yphantis, D. A., Lifsics, M. R., Saito, A., Akin, M., Reinke, K., and Williams, R. C., Jr. 1981 ; Proc. Natl. Acad. Sci. U. S. A 78, 1431-1435 27. Minami, Y., Murofushi, H., and Sakai, H. 1982 ; J. Biochem. Tokyo ; 92, 889-898 28. Minami, Y., and Sakai, H. 1983 ; J . Biochem. Tokyo ; 94, 20232033 29. Minami, Y., Endo, S., and Sakai, H. 1984 ; J. Biochem. Tokyo ; 96, 1481-1490 30. Leterrier, J-F., Liem, R. K. H., and Shelanski, M. L. 1982 ; J. Cell Biol. 9 5 , 982-986 31. Aamodt, E. J., and Williams, R. C., Jr. 1984 ; Biochemistry 2 3 , 6023-6031 32. Shelanski, M. L., Gaskin, F., and Cantor, C. R. 1973 ; Proc. Natl. Acad. Sci. U. S. A 70, 765-768 33. Nishida, E., Kumagai, H., Ohtsuki, I., and Sakai, H. 1979 ; J. Biochem. Tokyo ; 85, 1257-1266 34. Geisler, N., and Weber, K. 1981 ; J . Mol. Biol. 1 5 1 , 565-571 35. Laemmli, U. K. 1970 ; Nature 227, 680-685 H., 36. Lowry, 0. Rosebrough, N. J., Farr, A.L., and Randall, R. J. 1951 ; J. Bwl. Chem. 1 9 3 , 265-275 37. Heimann, R., Shelanski, M. L., and Liem, R. K. H. 1985 ; J. Biol. Chem. 2 6 0 , 12160-12166 38. Lazarides, E. 1980 ; Nature 283, 249-256 39. Osborn, M., and Weber, K. 1982 ; Cell 31, 303-306 40. Geisler, N., and Weber, K. 1981 ; Proc. Natl. Acad. Sci. U. S. A 78, 4120-4123 41. Geisler, N., Plessmann, U., and Weber, K. 1982 ; Nature 2 9 6 , 448-450 42. Steinert, P. M., Rice, R. H., Roop, D. R., Trus, B. L., and Steven, A. C. 1983 ; Nature 3 0 2 , 794-800 43. Willard, M., and Simon, C. 1981 ; J. Cell Biol. 89, 198-205 44. Sharp, G. A., Shaw, G., and Weber, K. 1982 ; Exp. Cell Res. 1 3 7 , 403-413 45. Hirokawa, N., Glicksman, M.A., and Willard, M. B. 1984 ; J. Cell Biol. 98, 1523-1536 46. Tsukita, S., Usukura, J., Tsukita, S., and Ishikawa, H. 1982 ; Neuroscience 7 , 2135-2147 47. Lee, Y. C., and Wolff, J. 1984 ; J. Biol. Chem. 259, 1226-1230 48. Sobue, K., Fujita, M., Muramoto, Y., and Kakiuchi, S. 1981 ; FEBS Lett. 132, 137-140 49. Kumagai, H., Nishida, E., Kotani, S., and Sakai, H. 1986 ; J. Biochem. Tokyo ; 9 , 521-525 50. Marcum, J. M., Dedman, J. R., Brinkley, B. R., and Means, A. R. 1978 ; Proc. Natl. Acad. Sci. U. S. A 75, 3771-3775 and enoxaparin.

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